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==Evolution==
This virus appears to have evolved only recently. An analysis of strains isolated in [[Europe]] ([[Austria]], [[France]] and [[Germany]]) showed that the clades C1b and C2b originated in 1994 (95% confidence interval 1992.7-1995.8) and 2002 (95% confidence interval 2001.6-2003.8) respectively.<ref name=Mirand2009>Mirand A, Schuffenecker I, Henquell C, Billaud G, Jugie G, Falcon D, Mahul A, Archimbaud C, Terletskaia-Ladwig E, Diedrich S, Huemer HP, Enders M, Lina B, Peigue-Lafeuille H, Bailly JL (2009) Phylogenetic evidence for a recent spread of two populations of human enterovirus 71 in European countries. J Gen Virol 91(9):2263-2277</ref>
==Pathology==
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